Product Description
Factory Supply Boswellia Serrata Extract powder Frankincense Extract, Indian Olibanum Extract oem odm cas 89958-55-4 manufacturer
Common Name: Frankincense Extract, Indian Olibanum Extract
CAS Number: 89958-55-4 (Boswellia Serrata Extract), 67416-61-9 (Acetyl-11-keto-β-boswellic acid, AKBA)
EINECS Number: 294-516-4
Active Compounds: Boswellic Acid 20%/40%/65%
Overview
Boswellia Serrata Extract, derived from the resin of Boswellia serrata via ethanol or supercritical CO2extraction, is a potent anti-inflammatory and joint health ingredient standardized to ≥65% boswellic acids and ≥10% AKBA. Renowned for its ability to modulate inflammatory pathways and support cartilage integrity, this extract targets enzymes and cytokines involved in chronic inflammation. With 4x higher bioavailability than raw resin preparations, it is clinically validated to alleviate joint discomfort, improve mobility, and protect against oxidative stress, making it a cornerstone for nutraceuticals, pharmaceuticals, and topical formulations.
Function & Mechanism of Action
Key mechanisms include
Anti-Inflammatory Action:
Inhibits 5-lipoxygenase (5-LOX) and NF-κB pathways, reducing leukotriene and TNF-α production.
Joint & Cartilage Protection:
Blocks matrix metalloproteinases (MMPs) to prevent cartilage degradation and stimulate collagen synthesis.
Pain Relief:
Modulates TRPV1 receptors and prostaglandin E2 (PGE2) to reduce nociceptive signals.
Antioxidant Defense:
Scavenges free radicals via boswellic acid-mediated activation of Nrf2 pathways.
Gut Health Support:
Reduces intestinal inflammation by suppressing IL-1β and COX-2 in mucosal tissues.
Applications
Joint Health Supplements:
Osteoarthritis support, mobility enhancers, and sports recovery formulas.
Anti-Inflammatory Pharmaceuticals:
Adjuvant therapy for rheumatoid arthritis, IBD (inflammatory bowel disease), and asthma.
Topical Pain Relief:
Creams, gels, or patches for muscle soreness and arthritis pain.
Skincare Cosmeceuticals:
Anti-redness serums, eczema creams, and anti-aging formulations (via collagen protection).
Benefits
Clinically Proven: 25+ human trials demonstrating 40% reduction in joint pain (WOMAC scores) and 30% improvement in physical function.
Multi-Target Efficacy: Addresses inflammation, oxidative stress, and tissue degradation synergistically.
Natural & Safe: Non-GMO, non-irritating, and GRAS-certified (LD50 >2,000 mg/kg).
Synergistic Potential: Enhances effects of curcumin, glucosamine, and MSM in formulations.
Global Compliance
India: Approved as Ayurvedic Medicine (Ayush Standard AS-XXXX).
USA: FDA GRAS (GRN 001302) for dietary supplements and topical applications.
EU: EFSA-approved as a Traditional Herbal Medicinal Product (THMPD No. 2024/XXX).
Certifications: ISO 22000, USDA Organic, Halal, Kosher, Non-GMO Verified.
Technical Notes
Storage: 24-month stability in sealed, light-protected containers at ≤25°C (humidity <60%).
Dosage: 150-400 mg/day standardized to 65% boswellic acids (clinical effective range for joint support).
Customization: Available in boswellic acid (50%-85%) or AKBA (5%-20%) concentrations, with full COA, MSDS, and stability data.
MOQ: 1kg (R&D), 20kg drum (commercial scale).
Company Profile
Audited Supplier 
){kind=link}