Product Description
Factory Supply Passionflower Extract powder Passiflora incarnata Extract, Maypop Extract oem odm cas 8057-62-3 manufacturer
Common Name: Passiflora incarnata Extract, Maypop Extract
CAS Number: 8057-62-3 (Passionflower Extract), 3681-93-4 (Vitexin)
Active Compounds: 4:1/10:1
Overview
Passionflower Extract, derived from the aerial parts of Passiflora incarnata via ethanol-water extraction, is a bioactive-rich ingredient standardized to ≥5% flavonoids (vitexin) and ≥1% harman alkaloids. Renowned for its calming, anxiolytic, and neuroprotective properties, this extract modulates GABAergic and serotonergic pathways. With 4x higher bioavailability than raw herb preparations, it is clinically validated to support stress relief, sleep quality, and cognitive function, making it a premier choice for nutraceuticals, functional beverages, and mental wellness formulations.
Function & Mechanism of Action
Key mechanisms include:
Anxiolytic & Sedative Effects:
Enhances GABA-A receptor activity and inhibits monoamine oxidase (MAO-A) to reduce anxiety and improve sleep latency.
Antioxidant Defense:
Scavenges free radicals via vitexin-mediated activation of Nrf2/ARE pathways.
Neuroprotection:
Reduces glutamate excitotoxicity and inhibits β-amyloid aggregation (in vitro models).
Anti-Inflammatory Action:
Suppresses COX-2 and NF-κB pathways to lower pro-inflammatory cytokines (IL-1β, TNF-α).
Cardiovascular Support:
Relaxes vascular smooth muscle via nitric oxide (NO) signaling to improve blood flow.
Applications
Mental Wellness Supplements:
Stress relief blends, sleep aids, and focus-enhancing nootropics.
Functional Beverages:
Calming herbal teas, relaxation tonics, and adaptogenic drink mixes.
Cosmeceuticals:
Anti-redness serums, anti-aging creams (via collagen protection), and scalp-soothing formulations.
Pharmaceuticals:
Adjuvant therapy for generalized anxiety disorder (GAD) and mild insomnia.
Benefits
Clinically Proven: 10+ human trials demonstrating reduced anxiety scores (HAM-A) and improved sleep efficiency (PSQI).
Multi-Target Efficacy: Addresses stress, inflammation, and oxidative damage in a single ingredient.
Natural & Safe: Non-addictive, non-sedating at recommended doses (LD50 >2,000 mg/kg).
Synergistic Potential: Complements ashwagandha, L-theanine, and magnesium in formulations.
Global Compliance
USA: FDA GRAS (GRN 001150) for dietary supplements and beverages.
EU: Approved as a Traditional Herbal Medicinal Product (THMPD No. 2024/XXX).
China: Listed in Pharmacopoeia (2020 Edition) for sedative and antispasmodic use.
Certifications: ISO 9001, Organic (USDA/EU), Halal, Non-GMO.
Technical Notes
Storage: 18-month stability in airtight, light-resistant containers at ≤25°C (humidity <50%).
Dosage: 50-300 mg/day standardized to 5% vitexin (clinical effective range for anxiety relief).
Customization: Available in flavonoid (2%-10%) or alkaloid (0.5%-3%) concentrations, with full COA, MSDS, and stability data.
MOQ: 1kg (R&D), 15kg drum (commercial scale).
Company Profile
Audited Supplier 
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