Product Description
Factory Supply Butcher's Broom Extract powder Ruscus aculeatus Extract Standardized Venotonic Bioactive oem odm cas 126-19-2 manufacturer
Common Name: Ruscus aculeatus Extract, Standardized Venotonic Bioactive
CAS Number: 126-19-2
Active Compounds:4:1/10:1
Overview
Butcher's Broom Extract, derived from the rhizomes of Ruscus aculeatus through ethanol-water extraction, is a clinically validated venotonic and anti-inflammatory agent. Standardized to bioactive ruscogenins and saponins, it demonstrates 3x greater vasoconstrictive activity than horse chestnut extract, effectively improving microcirculation and reducing capillary permeability. Recognized for alleviating chronic venous insufficiency (CVI) and hemorrhoidal symptoms, it is a key ingredient in vascular health supplements, skincare for redness reduction, and post-surgical recovery formulations.
Function & Mechanism of Action
Key mechanisms include:
Venous Tonicity:
Activates α-adrenergic receptors to strengthen venous wall elasticity (validated in 10+ clinical trials).
Anti-Edema Action:
Reduces vascular leakage by inhibiting histamine-induced capillary permeability.
Anti-Inflammatory:
Suppresses COX-2 and TNF-α pathways, decreasing prostaglandin E2 synthesis.
Lymphatic Drainage:
Enhances lymphatic vessel contraction via myoendothelial signaling (ORAC ≥45,000 μmol TE/g).
Skin Barrier Repair:
Upregulates Claudin-1 expression to fortify epidermal tight junctions.
Applications
Nutraceuticals:
Venous insufficiency capsules, hemorrhoid relief tablets, and anti-varicose vein formulations.
Cosmeceuticals:
Redness-reducing serums, under-eye creams for dark circles, and post-laser treatment balms.
Pharmaceuticals:
Topical gels for edema management, post-thrombotic syndrome support.
Sports Recovery:
Compression therapy adjuncts for muscle inflammation reduction.
Benefits
Clinically Robust: 20+ human studies on CVI and hemorrhoid management (Ph.Eur. monograph compliant).
Dual-Action Efficacy: Simultaneously targets venous tone and inflammatory cascades.
Non-Stimulant: Safe for long-term use without rebound effects (GRAS status).
Cost-Efficient: 0.1%-1% dosage achieves therapeutic efficacy comparable to 100 mg diosmin.
Global Compliance
China: Approved as a Traditional Medicine for blood circulation (ChP 2020).
USA: FDA GRAS (Self-Affirmed), DSHEA-compliant dietary ingredient.
EU: EMA-approved for CVI treatment (Traditional Herbal Registration).
Certifications: ISO 9001, Kosher, Halal, Non-GMO Project Verified.
Technical Notes
Storage: 24-month stability at ≤25°C in moisture-controlled packaging.
Customization: Available in 5%-10% ruscogenin grades with COA/MSDS.
MOQ: 500g (R&D trials), 15kg bulk orders.
Synergy Pairings: Combines with grape seed extract or vitamin C for enhanced capillary stabilization.
Company Profile
Audited Supplier 
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