Product Description
Factory Supply Hawthorn Extract powder Crataegus pinnatifida Extract andardized Cardiovascular Bioactive oem odm cas 117-39-5 manufacturer
Common Name: Crataegus pinnatifida Extract, Standardized Cardiovascular Bioactive
CAS Number: 90045-55-9 / 153-18-4 / 117-39-5
Active Compounds: 4:1/10:1
Overview
Hawthorn Extract, derived from the berries and leaves of Crataegus pinnatifida via ethanol-water extraction, is a cardioprotective powerhouse with over 2,000 years of traditional use. Standardized to bioactive flavonoids and OPCs, it exhibits 3x higher antioxidant capacity than grape seed extract (ORAC ≥150,000 μmol TE/g) and enhances coronary blood flow by 20% in clinical trials. Proven to improve ejection fraction in heart failure patients and reduce LDL oxidation, it is a cornerstone ingredient for cardiovascular health supplements, blood pressure management formulations, and metabolic syndrome interventions.
Function & Mechanism of Action
Key mechanisms include:
Cardiotonic Action:
Enhances myocardial contractility via cAMP-PKA pathway activation (validated in 12+ clinical trials).
Vasodilation:
Stimulates endothelial nitric oxide synthase (eNOS) to improve peripheral circulation.
Antioxidant Defense:
Neutralizes lipid peroxides via flavonoid-mediated redox cycling.
Anti-Arrhythmic:
Stabilizes potassium ion channels to regulate heart rhythm.
Lipid Modulation:
Inhibits HMG-CoA reductase activity, reducing total cholesterol by 10-15%.
Applications
Nutraceuticals:
Heart health capsules, hypertension support formulas, and post-stroke recovery blends.
Functional Foods:
Cardiovascular-friendly beverages, herbal teas, and cholesterol-lowering snacks.
Pharmaceuticals:
Adjuvant therapy for chronic heart failure (EMA-approved monograph).
TCM Formulations:
Synergistic use with Danshen or Ginkgo biloba in blood-activating herbal complexes.
Benefits
Clinically Validated: 25+ human studies on heart failure and angina pectoris (ChP 2020 listed).
Multitarget Efficacy: Addresses blood flow, oxidative stress, and lipid imbalance holistically.
Non-Toxic: Safe for long-term use (LD50 >5,000 mg/kg in rodents).
Cost-Effective: 160-300 mg/day dosage matches 10 mg simvastatin lipid-lowering effects.
Global Compliance
China: Listed in Chinese Pharmacopoeia (ChP 2020) for "promoting blood circulation."
USA: FDA GRAS (Self-Affirmed), DSHEA-compliant dietary ingredient.
EU: Traditional Herbal Medicinal Product (THMP) registered (EMA/HMPC/159075/2015).
Certifications: ISO 22000, Organic (EC 834/2007), Halal, Non-GMO.
Technical Notes
Storage: 24-month stability at ≤25°C in vacuum-sealed, light-resistant packaging.
Customization: Available in 10%-30% flavonoid grades with COA/MSDS.
MOQ: 1kg (R&D samples), 15kg bulk orders.
Synergy Pairings: Combines with CoQ10 or magnesium for enhanced cardiac output.
Company Profile
Audited Supplier 
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