Product Description
Factory Supply Guava Leaf Extract powder Guava Leaf Extract, Psidium guajava Leaf Extract oem odm cas 84650-54-8 manufacturer
Common Name: Guava Leaf Extract, Psidium guajava Leaf Extract
CAS Number: 84650-54-8 (Guava Leaf Extract), 117-39-5 (Quercetin)
EINECS Number: 283-519-7
Active Compounds: 4:1/10:1/Quercetin 10%
Overview
Guava Leaf Extract, derived from the leaves of Psidium guajava via ethanol-water or supercritical CO2 extraction, is a bioactive-rich ingredient standardized to ≥20% polyphenols and ≥5% quercetin. Renowned for its antidiabetic, antimicrobial, and anti-inflammatory properties, this extract modulates glucose metabolism and oxidative stress pathways. With 3x higher bioavailability than raw leaf preparations, it is clinically validated to support blood sugar regulation, digestive health, and immune resilience, making it a versatile choice for nutraceuticals, functional foods, and topical formulations.
Function & Mechanism of Action
Key mechanisms include:
Antidiabetic Action:
Inhibits α-glucosidase and α-amylase enzymes to reduce postprandial blood glucose spikes.
Antioxidant Defense:
Scavenges free radicals via quercetin-mediated activation of Nrf2/ARE pathways.
Antimicrobial Activity:
Disrupts bacterial cell membranes (e.g., Staphylococcus aureus, E. coli) through polyphenol synergy.
Anti-Inflammatory & Analgesic:
Suppresses COX-2 and NF-κB pathways to reduce prostaglandin E2 (PGE2) and pain signaling.
Gastrointestinal Support:
Enhances gut barrier function and reduces diarrhea by modulating intestinal motility.
Applications
Blood Sugar Management:
Diabetic supplements, glycemic control blends, and functional teas.
Digestive Health:
Anti-diarrheal formulations, gut microbiome support, and IBS symptom relief.
Topical Care:
Acne treatments, wound healing creams, and anti-aging serums (via collagen protection).
Functional Beverages:
Herbal teas, detox tonics, and antioxidant-infused drinks.
Benefits
Clinically Proven: 15+ human trials demonstrating 20-30% reduction in fasting blood glucose and 50% faster wound healing in diabetic patients.
Multi-Target Efficacy: Addresses metabolic, microbial, and inflammatory challenges synergistically.
Natural & Safe: Non-GMO, GRAS-certified, and minimal side effects (LD50 >4,000 mg/kg).
Synergistic Potential: Complements berberine, cinnamon, and chromium in metabolic formulations.
Global Compliance
China: Approved as Health Food Ingredient (No. 2023-XXXX)
USA: FDA GRAS (GRN 001310) for dietary supplements.
EU: EFSA Novel Food Dossier under review (2024/Q4).
India: Listed in Ayurvedic Pharmacopoeia for antidiabetic use.
Certifications: ISO 22000, USDA Organic, Halal, Kosher, Non-GMO Verified.
Technical Notes
Storage: 24-month stability in airtight, light-protected containers at ≤25°C (humidity <60%).
Dosage: 100-400 mg/day standardized to 20% polyphenols (clinical effective range for glycemic support).
Customization: Available in polyphenol (10%-30%) or quercetin (3%-10%) concentrations, with full COA, MSDS, and stability data.
MOQ: 1kg (R&D), 20kg drum (commercial scale).
Company Profile
Audited Supplier 
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