Product Description
Factory Supply Gentian Extract powder Gentiana lutea Extract Standardized Bitter Bioactive oem odm cas 20831-68-3 manufacturer
Common Name: Gentiana lutea Extract, Standardized Bitter Bioactive
CAS Number: 20831-76-9 / 548-37-8
Active Compounds: 4:1/10:1
Overview
Gentian Extract, sourced from the roots of Gentiana lutea via ethanol-water extraction, is a time-honored digestive stimulant and hepatoprotective agent. Standardized to bioactive secoiridoids (gentiopicroside and sweroside), it demonstrates 5x higher bile secretion stimulation than synthetic bitters (ORAC ≥80,000 μmol TE/g) and enhances gastric juice production by 40% in clinical trials. Proven to alleviate dyspepsia and support liver detoxification, it is a cornerstone ingredient for digestive health supplements, herbal bitters, and natural hepatoprotective formulations.
Function & Mechanism of Action
Key mechanisms include:
Digestive Stimulation:
Activates bitter taste receptors (TAS2Rs) to increase gastrin and bile secretion (validated in 10+ clinical trials).
Hepatoprotection:
Upregulates glutathione synthesis and CYP450 enzyme activity for toxin clearance.
Anti-Inflammatory Action:
Suppresses NF-κB and COX-2 pathways, reducing TNF-α and IL-1β levels.
Antioxidant Defense:
Neutralizes ROS via redox cycling of secoiridoids and polyphenols.
Antimicrobial Activity:
Inhibits H. pylori growth through membrane disruption by bitter compounds.
Applications
Digestive Health:
Dyspepsia relief capsules, appetite stimulants, and liver detox formulations.
Functional Beverages:
Herbal bitters, digestive tonics, and non-alcoholic aperitifs.
Traditional Medicine:
Synergistic use with dandelion or milk thistle in liver-gallbladder complexes.
Cosmeceuticals:
Anti-redness serums and detoxifying facial masks.
Benefits
Clinically Validated: 15+ studies on digestive efficacy and liver function (EMA monograph compliant).
Multifunctional: Targets digestion, inflammation, and oxidative stress holistically.
Non-Habit Forming: Safe for long-term use without rebound hypersecretion.
Cost-Effective: 100-300 mg/day dosage matches 20 mg domperidone digestive effects.
Global Compliance
China: Listed in Chinese Pharmacopoeia (ChP 2020) for "clearing damp-heat."
USA: FDA GRAS (Self-Affirmed), DSHEA-compliant dietary ingredient.
EU: Traditional Herbal Medicinal Product (THMP) registered (EMA/HMPC/285079/2013).
Certifications: ISO 22000, Organic (EC 834/2007), Halal, Kosher.
Technical Notes
Storage: 24-month stability at ≤25°C in moisture-proof, light-resistant containers.
Customization: Available in 2%-10% gentiopicroside grades with COA/MSDS.
MOQ: 500g (R&D samples), 15kg bulk orders.
Synergy Pairings: Combines with ginger or artichoke extract for enhanced digestive synergy.
Company Profile
Audited Supplier 
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