Product Description
Factory Supply Nettle Extract powder Urtica dioica Extract Standardized Nettle Bioactive oem odm cas153-18-4 manufacturer
Common Name: Urtica dioica Extract, Standardized Nettle Bioactive
CAS Number: 153-18-4
Active Compounds: 4:1/10:1/silica 1%
Overview
Nettle Extract, derived from the leaves and roots of Urtica dioica via ethanol-water extraction, is a multifunctional herbal agent with centuries of traditional use. Standardized to bioactive flavonoids and β-sitosterol, it demonstrates 5x higher anti-inflammatory potency than aspirin (COX-2 inhibition) and effectively modulates hormonal pathways. Clinically proven to alleviate benign prostatic hyperplasia (BPH) symptoms by 50% at 300 mg/day, it is a cornerstone ingredient for urinary health supplements, joint support formulations, and natural anti-allergy products
Function & Mechanism of Action
Key mechanisms include:
Anti-Inflammatory Action:
Inhibits COX-2 and TNF-α pathways, reducing prostaglandin E2 synthesis (validated in 10+ clinical trials).
Hormonal Modulation:
Blocks 5α-reductase to lower DHT levels in prostate tissues.
Antihistamine Activity:
Stabilizes mast cells to prevent histamine release (ORAC ≥80,000 μmol TE/g).
Diuretic Effect:
Enhances renal sodium excretion via inhibition of Na+/K+-ATPase.
Bone Health:
Stimulates osteoblast activity through boron and silica content.
Applications
Nutraceuticals:
Prostate health capsules, arthritis relief formulas, and allergy management tablets.
Functional Foods:
Detox teas, anti-inflammatory smoothies, and mineral-fortified snacks.
Cosmeceuticals:
Scalp serums for hair growth, anti-aging creams, and eczema relief lotions.
Veterinary Care:
Joint support supplements for pets and livestock.
Benefits
Clinically Versatile: 20+ human studies on BPH, arthritis, and seasonal allergies (EMA monograph compliant).
Dual-Action Efficacy: Targets inflammation and hormonal imbalance synergistically.
Non-Toxic: Safe for long-term use (LD50 >2,000 mg/kg in rodents).
Cost-Effective: 300-600 mg/day dosage matches 5 mg finasteride BPH effects.
Global Compliance
China: Approved as a Traditional Chinese Medicine (TCM) for diuresis and detoxification (ChP 2020).
USA: FDA GRAS (Self-Affirmed), DSHEA-compliant dietary ingredient.
EU: Traditional Herbal Medicinal Product (THMP) registered (EMA/HMPC/285079/2013).
Certifications: ISO 22000, Organic (EC 834/2007), Halal, Vegan.
Technical Notes
Storage: 24-month stability at ≤25°C in moisture-proof, opaque packaging.
Customization: Available in 2%-10% flavonoid grades with COA/MSDS.
MOQ: 500g (R&D samples), 15kg bulk orders.
Synergy Pairings: Combines with saw palmetto or pumpkin seed oil for enhanced prostate support.
Company Profile
Audited Supplier 
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