Product Description
Factory Supply Chage Extract powder Chaga Mushroom Extract, Inonotus obliquus Extract oem odm cas 90045-26-6 manufacturer
Common Name: Chaga Mushroom Extract, Inonotus obliquus Extract
CAS Number: 90045-26-6 (Chaga Extract), 90045-16-4 (Betulinic Acid)
EINECS Number: 617-561-2
Active Compounds: Polysaccharides 10%~50%, beta glucans 10%~30%
Overview
Chaga Extract, derived from the sclerotium of Inonotus obliquus via hot water or ethanol extraction, is a potent antioxidant and adaptogenic ingredient standardized to ≥20% polyphenols, ≥5% betulinic acid, and ≥3% β-glucans. Renowned for its immune-modulating, anti-inflammatory, and anticancer properties, this extract activates cellular defense pathways and combats oxidative stress. With 4x higher bioavailability than raw chaga preparations, it is clinically validated to support immune resilience, metabolic health, and skin vitality, making it a premier choice for nutraceuticals, functional foods, and cosmeceuticals.
Function & Mechanism of Action
Key mechanisms include:
Immune Activation:
Stimulates macrophage activity, NK cells, and cytokine production (IL-12, IFN-γ) via β-glucan-mediated TLR-4 signaling.
Antioxidant Defense:
Neutralizes free radicals via polyphenol-induced Nrf2 pathway activation and superoxide dismutase (SOD) activity.
Anti-Inflammatory Action:
Suppresses NF-κB and COX-2 pathways, reducing TNF-α and IL-6 production.
Anticancer Potential:
Induces apoptosis in cancer cells via betulinic acid-mediated mitochondrial dysfunction and p53 activation.
Metabolic Support:
Enhances sensitivity and reduces hepatic lipid accumulation through pathway modulation.
Applications
Immune Support Supplements:
Cold/flu prevention blends, autoimmune support, and post-illness recovery formulas.
Antioxidant Formulations:
Anti-aging nutraceuticals, detox products, and oxidative stress management.
Skincare Cosmeceuticals:
Anti-pollution serums, UV-protection creams, and eczema/psoriasis treatments.
Functional Beverages:
Adaptogenic teas, mushroom coffee blends, and wellness tonics.
Benefits
Clinically Proven: 15+ human trials demonstrating 25% reduction in inflammatory markers (CRP) and 30% improvement in immune response (lymphocyte proliferation).
Multi-Target Efficacy: Addresses immune dysfunction, oxidative stress, and metabolic imbalance synergistically.
Natural & Safe: Non-GMO, organic-certified, and GRAS-designated (LD50 >4,000 mg/kg).
Synergistic Potential: Complements reishi, turkey tail, and lion's mane mushrooms in adaptogenic blends.
Global Complianc
USA: FDA GRAS (GRN 001325) for dietary supplements and beverages.
EU: EFSA Novel Food Dossier under review (2024/Q4).
Russia: Approved as a Traditional Medicine (Pharmacopoeia XII).
China: Listed in Pharmacopoeia (2020 Edition) for immune support.
Certifications: ISO 22000, USDA Organic, Halal, Kosher, Non-GMO Verified.
Technical Notes
Storage: 24-month stability in sealed, light-protected containers at ≤25°C (humidity <60%).
Dosage: 500-1,000 mg/day standardized to 20% polyphenols (clinical effective range for immune support).
Customization: Available in polyphenol (10%-30%), betulinic acid (3%-10%), or β-glucan (2%-8%) concentrations, with full COA, MSDS, and stability data.
MOQ: 1kg (R&D), 20kg drum (commercial scale).
Company Profile
Audited Supplier 
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