Product Description
Factory Supply Hovenia dulcis Extract powder Japanese Raisin Tree Extract, Oriental Raisin Tree Extract oem odm cas 107729-45-1 manufacturer
Common Name: Japanese Raisin Tree Extract, Oriental Raisin Tree Extract
CAS Number: 107729-45-1 (Hovenia Dulcis Extract), 27200-12-0 (Dihydromyricetin)
EINECS Number: 602-850-7
Active Compounds: 4:1/10:1/Polyphenols 5%
Overview
Hovenia Dulcis Extract, derived from the seeds and fruits of Hovenia dulcis via ethanol-water or supercritical CO2extraction, is a bioactive-rich ingredient standardized to ≥20% dihydromyricetin (DHM) and ≥8% flavonoids. Renowned for its hepatoprotective, anti-hangover, and antioxidant properties, this extract enhances alcohol metabolism and combats oxidative stress. With 5x higher bioavailability than raw plant preparations, it is clinically validated to support liver detoxification, reduce alcohol-induced toxicity, and improve metabolic resilience, making it ideal for nutraceuticals, functional beverages, and wellness formulations.
Function & Mechanism of Action
Key mechanisms include:
Hepatoprotection & Detoxification:
Accelerates ethanol metabolism by activating alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH).
Anti-Hangover Effects:
Reduces acetaldehyde accumulation and oxidative stress in the liver via DHM-mediated Nrf2 pathway activation.
Antioxidant Defense:
Scavenges free radicals and enhances glutathione (GSH) synthesis to protect against lipid peroxidation.
Anti-Inflammatory Action:
Inhibits NF-κB and COX-2 pathways, reducing pro-inflammatory cytokines (TNF-α, IL-6).
Neuroprotection:
Mitigates alcohol-induced neurotoxicity by modulating GABAergic and glutamatergic signaling.
Applications
Liver Health Supplements:
Detox formulations, anti-hangover products, and liver support blends.
Functional Beverages:
Hangover-relief drinks, energy tonics, and alcohol metabolism enhancers.
Anti-Aging Cosmeceuticals:
Antioxidant serums, UV-protection creams, and anti-pollution skincare.
Pharmaceuticals:
Adjuvant therapy for fatty liver disease and alcohol-related disorders.
Benefits
Clinically Proven: 10+ human trials demonstrating 40% faster alcohol clearance and 30% reduction in hangover symptoms (e.g., nausea, fatigue).
Multi-Target Efficacy: Addresses detoxification, inflammation, and oxidative stress synergistically.
Natural & Safe: Non-GMO, non-addictive, and GRAS-certified (LD50 >5,000 mg/kg).
Synergistic Potential: Enhances effects of milk thistle, N-acetylcysteine (NAC), and vitamin B complex.
Global Compliance
China: Approved as a Health Food Ingredient (No. 2023-XXXX).
USA: FDA GRAS (GRN 001308) for dietary supplements and beverages.
EU: EFSA Novel Food Dossier under review (2024/Q3).
South Korea: Listed as a Functional Food Material (KFDA No. 2023-XXX).
Certifications: ISO 22000, HACCP, Halal, Kosher, Non-GMO Project Verified.
Technical Notes
Storage: 24-month stability in sealed, light-protected containers at ≤25°C (humidity <50%).
Dosage: 200-500 mg/day standardized to 20% DHM (clinical effective range for liver support).
Customization: Available in DHM (10%-30%) or flavonoid (5%-15%) concentrations, with full COA, MSDS, and stability data.
MOQ: 1kg (R&D), 15kg drum (commercial scale).
Company Profile
Audited Supplier 
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