Product Description
Factory Supply Curcumin powder Turmeric Extract, Curcuminoids oem odm cas 458-37-7 manufacturer
Common Name: Turmeric Extract, Curcuminoids
CAS Number: 458-37-7 (Curcumin), 24939-16-0 (Curcuminoids)
EINECS Number: 207-280-5
Active Compounds: 95% ,98%
Overview
Curcumin, derived from the rhizomes of Curcuma longa (turmeric) via ethanol or supercritical CO2 extraction, is a bioactive polyphenol standardized to ≥95% curcuminoids. Renowned for its potent anti-inflammatory, antioxidant, and anticancer properties, this extract modulates key molecular pathways involved in chronic diseases. With low intrinsic bioavailability enhanced by formulations (e.g., liposomal or piperine-combined), it is clinically validated to support joint health, cognitive function, and metabolic balance, making it a cornerstone ingredient for nutraceuticals, pharmaceuticals, and functional foods.
Function & Mechanism of Action
Key mechanisms include:
Anti-Inflammatory Action:
Inhibits NF-κB, COX-2, and LOX pathways, reducing pro-inflammatory cytokines (TNF-α, IL-6).
Antioxidant Defense:
Activates Nrf2/ARE pathways to boost glutathione synthesis and neutralize free radicals.
Anticancer Potential:
Induces apoptosis in cancer cells via p53 activation and suppresses angiogenesis ( inhibition).
Neuroprotection:
Reduces β-amyloid plaques and tau protein hyperphosphorylation in Alzheimer's models.
Metabolic Health:
Enhances sensitivity via activation and reduces hepatic lipid accumulation.
Applications
Joint Health Supplements:
Osteoarthritis formulations, anti-inflammatory blends, and mobility enhancers.
Cognitive Health:
Nootropic stacks for memory support and neurodegenerative disease prevention.
Functional Foods:
Golden milk powders, antioxidant beverages, and anti-aging snacks.
Cosmeceuticals:
Brightening serums, acne treatments, and anti-aging creams (via collagen protection).
Pharmaceuticals:
Adjuvant therapy for cancer, diabetes, and cardiovascular diseases.
Benefits
Clinically Proven: 50+ human trials demonstrating 30-40% reduction in joint pain (WOMAC scores) and 20% improvement in cognitive function (ADAS-Cog).0
Multi-Target Efficacy: Addresses inflammation, oxidative stress, and metabolic dysregulation holistically.
Natural & Safe: Non-GMO, GRAS-certified, and minimal side effects (LD50 >2,000 mg/kg).
Synergistic Potential: Enhances effects of piperine (bioavailability booster), resveratrol, and omega-3s.
Global Compliance
USA: FDA GRAS (GRN 000737) for food and supplements.
EU: EFSA-approved for use as a food colorant (E100) and health claims under review (2024).
India: Approved as Ayurvedic Medicine (Ayush Standard AS-XXXX).
China: Listed in Pharmacopoeia (2020 Edition) for anti-inflammatory use.
Certifications: ISO 22000, USDA Organic, Halal, Kosher, Non-GMO Verified.
Technical Notes
Storage: 24-month stability in airtight, light-protected containers at ≤25°C (humidity <60%).
Dosage: 500-2,000 mg/day (bioavailability-enhanced forms: 100-500 mg/day).
Customization: Available in curcuminoid concentrations (50%-95%) with COA, MSDS, and stability data.
MOQ: 1kg (R&D), 20kg drum (commercial scale).
Company Profile
Audited Supplier 
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