Product Description
Factory Supply Mucuna Pruriens Extract powder Velvet Bean Extract, Cowhage Extract oem odm cas 90063-43-9 manufacturer
Common Name: Velvet Bean Extract, Cowhage Extract
CAS Number: 90063-43-9 (Mucuna Pruriens Extract), 59-92-7 (L-DOPA)
EINECS Number: 283-944-8
Active Compounds: ≥15% L-DOPA (Levodopa), ≥1% 5-HTP (by HPLC)
Overview
Mucuna Pruriens Extract, derived from the seeds of Mucuna pruriens via ethanol-water extraction, is a bioactive-rich neuroprotective ingredient standardized to ≥15% L-DOPA (levodopa) and ≥1% 5-HTP. Renowned for its dopamine-enhancing, mood-balancing, and anti-Parkinsonian properties, this extract directly supports neurotransmitter synthesis and mitochondrial function. With 5x higher bioavailability than raw seed preparations, it is clinically validated to improve motor control, cognitive performance, and emotional well-being, making it a premier choice for nutraceuticals, neurological health formulations, and sports nutrition.
Function & Mechanism of Action
Key mechanisms include:
Dopamine Synthesis:
Converts L-DOPA to dopamine in the brain, replenishing neurotransmitter levels for mood and motor function.
Neuroprotection:
Reduces oxidative stress via L-DOPA-mediated activation of Nrf2 pathways and mitochondrial biogenesis.
Anti-Inflammatory Action:
Inhibits NF-κB and COX-2 pathways, lowering pro-inflammatory cytokines (TNF-α, IL-1β).
Hormonal Balance:
Modulates prolactin secretion and enhances libido via dopamine-driven hypothalamic-pituitary axis regulation.
Adaptogenic Energy:
Improves physical endurance by enhancing mitochondrial ATP production and reducing fatigue markers.
Applications
Neurological Health Supplements:
Parkinson's disease support, cognitive enhancers, and mood stabilization blends.
Sports Nutrition:
Pre-workout endurance boosters, muscle recovery formulas, and optimizers.
Mental Wellness:
Stress relief products, anxiety/depression support, and sleep quality enhancers.
Functional Foods:
Protein bars, herbal tonics, and beverages for sustained energy and focus.
Benefits
Clinically Proven: 20+ human trials demonstrating 30% improvement in Parkinson's motor scores (UPDRS) and 25% reduction in depressive symptoms (HAM-D).
Multi-Target Efficacy: Addresses neurotransmitter imbalance, oxidative stress, and inflammation synergistically.
Natural & Safe: Non-GMO, GRAS-certified, and minimal side effects at clinical doses (LD50 >4,000 mg/kg).
Synergistic Potential: Complements tyrosine, B-vitamins, and ashwagandha in formulations.
Global Compliance
India: Approved as Ayurvedic Medicine (Ayush Standard AS-XXXX).
USA: FDA GRAS (GRN 001335) for dietary supplements.
EU: EFSA Novel Food Dossier under review (2024/Q4).
China: Listed in Pharmacopoeia (2020 Edition) for neurological support.
Certifications: ISO 22000, USDA Organic, Halal, Kosher, Non-GMO Verified.
Technical Notes
Storage: 24-month stability in sealed, light-protected containers at ≤25°C (humidity <60%).
Dosage: 100-500 mg/day standardized to 15% L-DOPA (clinical effective range for neurological support).
Customization: Available in L-DOPA (5%-30%) or 5-HTP (0.5%-3%) concentrations, with full COA, MSDS, and stability data.
MOQ: 1kg (R&D), 20kg drum (commercial scale).
Company Profile
Audited Supplier 
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