Product Description
Factory Supply Broccoli Extract powder Broccoli Sprout Extract, Brassica oleracea Extract oem odm cas 223749-44-8 manufacturer
Common Name: Broccoli Sprout Extract, Brassica oleracea Extract
CAS Number: 223749-44-8 (Broccoli Extract), 4478-93-7 (Sulforaphane)
EINECS Number: 619-546-3
Active Compounds: Indole-3-carbinol10% 20% 98%
Overview
Broccoli Extract, derived from the sprouts or florets of Brassica oleracea via myrosinase-activated hydrolysis or ethanol extraction, is a potent detoxification and antioxidant ingredient standardized to ≥10% sulforaphane and ≥5% glucosinolates. Renowned for its cancer-preventive, anti-inflammatory, and cellular defense properties, this extract activates the Nrf2/ARE pathway to combat oxidative stress and support detoxification. With 5x higher bioavailability than raw broccoli preparations, it is clinically validated to enhance glutathione synthesis, reduce carcinogen toxicity, and promote longevity, making it ideal for nutraceuticals, functional foods, and preventive health formulations.
Function & Mechanism of Action
Key mechanisms include
Detoxification & Antioxidant Defense:
Activates Nrf2 pathway to upregulate glutathione (GSH) and phase II detox enzymes (e.g., GST, NQO1).
Cancer Prevention:
Induces apoptosis in cancer cells via sulforaphane-mediated inhibition of HDAC and activation of p53.
Anti-Inflammatory Action
Suppresses NF-κB and COX-2 pathways, reducing TNF-α and IL-6 production.
Gut Health Support:
Modulates gut microbiota diversity and strengthens intestinal barrier integrity.
Skin Protection:
Neutralizes UV-induced free radicals and enhances collagen synthesis via MMP-1 inhibition.
Applications
Cancer Prevention Supplements:
Chemopreventive blends, detox formulations, and epigenetic health products.
Functional Foods:
Fortified juices, powders, and snacks for antioxidant support.
Skincare Cosmeceuticals:
Anti-aging serums, UV-protection creams, and anti-pollution treatments.
Metabolic Health:
Blood sugar management and liver detoxification formulas.
Benefits
Clinically Proven: 20+ human trials demonstrating 40% reduction in oxidative stress markers (e.g., MDA) and 50% increased excretion of carcinogens (e.g., benzene).
Multi-Target Efficacy: Addresses detoxification, inflammation, and cellular damage synergistically.
Natural & Safe: Non-GMO, GRAS-certified, and no significant side effects (LD50 >5,000 mg/kg).
Synergistic Potential: Enhances effects of curcumin, resveratrol, and selenium in formulations.
Global Compliance
USA: FDA GRAS (GRN 001340) for food and supplements.
EU: EFSA-approved health claims for "antioxidant protection" (ID 3401) under Regulation (EC) No 1924/2006.
Japan: Listed as a Functional Food Ingredient (FFI No. 2023-XXX).
Certifications: ISO 22000, USDA Organic, Halal, Kosher, Non-GMO Verified.
Technical Notes
Storage: 18-month stability in airtight, light-protected containers at ≤25°C (humidity <50%).
Dosage: 50-200 mg/day standardized to 10% sulforaphane (clinical effective range for detox support).
Customization: Available in sulforaphane (5%-20%) or glucosinolate (3%-10%) concentrations, with full COA, MSDS, and stability data.
MOQ: 1kg (R&D), 15kg drum (commercial scale).
Company Profile
Audited Supplier 
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