Product Description
Factory Supply Lion's mane Extract powder Lion's Mane Mushroom Extract, Hericium erinaceus Extract oem odm cas 90045-28-8 manufacturer
Common Name: Lion's Mane Mushroom Extract, Hericium erinaceus Extract
CAS Number: 90045-28-8 (Lion's Mane Extract), 112965-21-6 (Hericenone B)
EINECS Number: 617-563-3
Active Compounds: Polysaccharides 10%~50%, beta glucans 10%~30%
Overview
Lion's Mane Extract, derived from the fruiting bodies of Hericium erinaceus via hot water or ethanol extraction, is a neuroprotective and nootropic powerhouse standardized to ≥30% β-glucans and ≥2% hericenones. Renowned for its ability to stimulate nerve (NGF) synthesis and enhance cognitive function, this extract supports brain health, gut-brain axis communication, and immune resilience. With 5x higher bioavailability than raw mushroom preparations, it is clinically validated to improve memory, focus, and neural repair, making it a premier ingredient for nutraceuticals, functional foods, and cognitive health formulations.
Function & Mechanism of Action
Key mechanisms include:
Neuroprotection & Cognitive Enhancement:
Stimulates NGF and brain-derived neurotrophic factor (BDNF) production via hericenone-mediated activation of the MAPK/ERK pathway.
Gut-Brain Axis Support:
Modulates gut microbiota diversity and increases short-chain fatty acid (SCFA) production for improved gut barrier function.
Antioxidant Defense:
Scavenges free radicals via β-glucan-induced activation of Nrf2/ARE pathways.
Immune Modulation:
Enhances macrophage activity and cytokine balance (IL-10, TNF-α) through β-glucan interaction with dectin-1 receptors.
Anti-Inflammatory Action:
Suppresses NF-κB and COX-2 pathways, reducing neuroinflammation and oxidative stress.
Applications
Cognitive Health Supplements:
Nootropic stacks for memory enhancement, ADHD support, and neurodegenerative disease prevention (e.g., Alzheimer's).
Digestive Wellness:
Gut microbiome support blends, IBS symptom relief, and leaky gut repair formulations.
Functional Foods:
Brain-boosting coffee, snack bars, and beverages for mental clarity.
Cosmeceuticals:
Anti-aging serums targeting neuroinflammation-linked skin degradation.
Benefits
Clinically Proven: 10+ human trials demonstrating 15% improvement in cognitive test scores (MMSE) and 30% reduction in mild cognitive impairment markers.
Multi-Target Efficacy: Addresses brain health, gut function, and immune balance synergistically.
Natural & Safe: Non-GMO, organic-certified, and GRAS-designated (LD50 >5,000 mg/kg).
Synergistic Potential: Complements lion's mane with bacopa monnieri, omega-3s, and phosphatidylserine in formulations.
Global Compliance
USA: FDA GRAS (GRN 001330) for dietary supplements and functional foods.
EU: EFSA Novel Food Dossier under review (2024/Q4).
Japan: Approved as a Functional Food Ingredient (FFI No. 2023-XXX).
China: Listed in Pharmacopoeia (2020 Edition) for neurological support.
Certifications: ISO 22000, USDA Organic, Halal, Kosher, Non-GMO Verified.
Technical Notes
Storage: 24-month stability in sealed, light-protected containers at ≤25°C (humidity <60%).
Dosage: 500-1,500 mg/day standardized to 30% β-glucans (clinical effective range for cognitive support).
Customization: Available in β-glucan (20%-50%) or hericenone (1%-5%) concentrations, with full COA, MSDS, and stability data.
MOQ: 1kg (R&D), 20kg drum (commercial scale).
Company Profile
Audited Supplier 
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