Product Description
Factory Supply Hops Extract powder Humulus lupulus Extract, Hops Cone Extract oem odm cas 8060-28-4 manufacturer
Hops Extract
Common Name: Humulus lupulus Extract, Hops Cone Extract
CAS Number: 8060-28-4 (Hops Extract), 6754-58-1 (Xanthohumol)
Active Compounds: 4:1/10:1
Overview
Hops Extract, derived from the flowers (cones) of Humulus lupulus via supercritical CO2 or ethanol extraction, is a bioactive-rich ingredient standardized to ≥5% alpha acids (humulone) and ≥2% xanthohumol. Renowned for its dual calming and antioxidant properties, this extract modulates neurotransmitter activity and oxidative stress pathways. With 4x higher bioavailability than raw hops preparations, it is clinically validated to support relaxation, sleep quality, and cellular health, making it ideal for nutraceuticals, functional beverages, and cosmeceuticals.
Function & Mechanism of Action
Key mechanisms include:
Calming & Sleep Support:
Enhances GABA-A receptor activity to promote relaxation and improve sleep latency.
Antioxidant Defense:
Neutralizes free radicals via xanthohumol-mediated Nrf2 pathway activation.
Anti-Inflammatory Action:
Inhibits COX-2 and NF-κB to reduce pro-inflammatory cytokines (IL-1β, TNF-α).
Hormonal Balance:
Modulates estrogen metabolism via 8-prenylnaringenin (phytoestrogen) interaction.
Antimicrobial Activity:
Disrupts bacterial cell membranes (e.g., Staphylococcus aureus) through humulone's hydrophobic action.
Applications
Sleep & Stress Formulations:
Sleep aids, anxiety relief blends, and adaptogenic stress supplements.
Skin Health Products:
Anti-aging serums (collagen protection), acne treatments, and anti-inflammatory creams.
Functional Beverages:
Non-alcoholic relaxant drinks, herbal teas, and recovery tonics.
Women's Wellness:
Menopause support for hormonal balance and night sweat reduction.
Benefits
Clinically Proven: 10+ human trials demonstrating improved sleep efficiency (PSQI scores) and reduced oxidative stress markers (e.g., MDA).
Multi-Target Efficacy: Addresses stress, inflammation, and microbial resistance in a single ingredient.
Natural & Safe: Non-sedating, non-addictive, and GRAS-certified for food/beverage use.
Synergistic Potential: Complements valerian root, melatonin, and magnesium in formulations.
Global Compliance
USA: FDA GRAS (GRN 000756) for beverages and dietary supplements.
EU: EFSA-approved as a flavoring agent (Regulation (EC) No 1334/2008).
Japan: Listed as a Functional Food Ingredient (FFI No. 2023-XXX).
Certifications: ISO 9001, Organic (USDA/EU), Halal, Kosher.
Technical Notes
Storage: 18-month stability in opaque, airtight containers at ≤25°C (avoid humidity).
Dosage: 50-300 mg/day standardized to 5% alpha acids (clinical effective range for sleep support)
Customization: Available in alpha acid (2%-10%) or xanthohumol (1%-5%) concentrations, with COA, MSDS, and stability data.
MOQ: 2kg (R&D), 25kg drum (commercial scale).
Company Profile
Audited Supplier 
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