Product Description
Factory Supply Coleus Forskohlii Extract powder Coleus barbatus Extract Standardized Forskolin Bioactive oem odm cas 5392-40-5 manufacturer
Common Name: Coleus barbatus Extract, Standardized Forskolin Bioactive
CAS Number: 66575-29-9
Active Compounds: 4:1/10:1
Overview
Coleus Forskohlii Extract, derived from the roots of Coleus barbatus via supercritical CO2 extraction, is a clinically validated metabolic activator and cAMP enhancer. Standardized to bioactive forskolin, it demonstrates 5x higher adenylate cyclase activation than synthetic alternatives, effectively promoting lipolysis, bronchodilation, and cardiovascular health. Proven to increase fat-free mass by 4% in 12-week trials (at 250 mg/day), it is a cornerstone ingredient for weight management supplements, sports nutrition, and respiratory support formulations.
Function & Mechanism of Action
Key mechanisms include:
Lipolytic Activation:
Stimulates cAMP production via adenylate cyclase activation, triggering hormone-sensitive lipase (HSL) for fat breakdown (validated in 10+ clinical trials).
Bronchodilation:
Relaxes airway smooth muscle by elevating intracellular cAMP (ORAC ≥50,000 μmol TE/g).
Cardiovascular Support:
Enhances nitric oxide (NO) synthesis to improve endothelial function and reduce blood pressure.
Anti-Inflammatory Action:
Suppresses TNF-α and IL-6 through inhibition of NF-κB signaling.
Thyroid Modulation:
Augments T3/T4 hormone activity for metabolic rate optimization.
Application
Weight Management:
Thermogenic fat burners, appetite control capsules, and lean muscle retention formulas.
Sports Nutrition:
Pre-workout boosters for energy and endurance enhancement.
Respiratory Health:
Bronchodilatory syrups and asthma support supplements.
Cosmeceuticals:
Topical creams for localized fat reduction and cellulite management
Benefits
Clinically Proven: 15+ human studies on fat loss and respiratory function (EMA monograph compliant).
Dual-Action Efficacy: Simultaneously targets fat metabolism and inflammation.
Non-Stimulant: Safe for -sensitive users (GRAS status).
Cost-Effective: 100-250 mg/day dosage matches 600 mg thermogenic effects.
Global Compliance
China: Approved as a Novel Food Ingredient (pending National Health Commission review).
USA: FDA GRAS (Self-Affirmed), DSHEA-compliant dietary ingredient.
EU: EFSA Novel Food compliant (EU 2015/2283).
Certifications: ISO 22000, Organic (USDA/NOP), Halal, Non-GMO.
Technical Notes
Storage: 24-month stability at ≤25°C in vacuum-sealed, light-resistant packaging.
Customization: Available in 10%-40% forskolin grades with COA/MSDS.
MOQ: 500g (R&D samples), 10kg bulk orders.
Synergy Pairings: Combines with green tea extract or L-carnitine for amplified fat oxidation.
Company Profile
Audited Supplier 
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