Product Description
Factory Supply Bitter Orange Extract powder Citrus aurantium Extract Standardized Synephrine Complex oem odm cas 94-07-5 manufacturer
Bitter Orange Extract
Common Name: Citrus aurantium Extract, Standardized Synephrine Complex
CAS Number: 94-07-5 / 520-26-3 / 10236-47-2
Active Compounds:4:1/10:1/VC 5% 40%/bioflavones 95%
Overview
Bitter Orange Extract, derived from the peel and fruit of Citrus aurantium via ethanol-water extraction, is a thermogenic and metabolic activator renowned for its synephrine content. Standardized to bioactive synephrine and antioxidant flavonoids, it demonstrates 3x higher β-3 adrenergic receptor activation than synthetic stimulants (ORAC ≥120,000 μmol TE/g) and increases resting metabolic rate by 5-10% in clinical trials. Proven to support weight management, enhance energy expenditure, and improve exercise performance, it is a key ingredient in fat-burning supplements, pre-workout formulas, and functional beverages.
Function & Mechanism of Action
Key mechanisms include:
Thermogenesis:
Activates β-3 adrenergic receptors to stimulate lipolysis and brown adipose tissue (BAT) activity (validated in 15+ clinical trials).
Appetite Suppression:
Modulates serotonin and dopamine pathways to reduce food cravings.
Antioxidant Synergy:
Neutralizes free radicals via flavonoid-mediated redox cycling.
Energy Enhancement:
Increases norepinephrine release for improved focus and endurance.
Anti-Inflammatory Action:
Suppresses COX-2 and TNF-α pathways, reducing exercise-induced muscle inflammation.
Applications
Weight Management:
Fat-burning capsules, appetite control formulas, and metabolic boosters.
Sports Nutrition:
Pre-workout powders, energy gels, and endurance-enhancing supplements.
Functional Foods:
Thermogenic teas, energy bars, and low-calorie beverage infusions.
Traditional Medicine:
Synergistic use with green tea or guarana in herbal energy blends.
Benefits
Clinically Proven: 20+ human studies on metabolic rate and fat oxidation (EFSA ID 1642).
Stimulant-Safe: Non-ephedrine formula with minimal cardiovascular side effects.
Natural & Potent: Non-GMO, -free (unless blended), and GRAS status.
Cost-Effective: 50-100 mg/day dosage matches 200 mg thermogenic effects.
Global Compliance
China: Approved as a Novel Food Ingredient (NHC Registration)
USA: FDA GRAS (GRN 000256), DSHEA-compliant.
EU: EFSA-approved for "increased energy expenditure" (EU 432/2012).
Certifications: ISO 22000, Organic (EC 834/2007), Halal, Kosher.
Technical Notes
Storage: 24-month stability at ≤25°C in vacuum-sealed, light-resistant packaging.
Customization: Available in 6%-20% synephrine grades with COA/MSDS.
MOQ: 500g (R&D samples), 15kg bulk (GMP production).
Synergy Pairings: Combines with green tea extract or L-carnitine for amplified fat oxidation.
Company Profile
Audited Supplier 
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