Product Description
Factory Supply Andrographis Extract powder Andrographis paniculata Extract Standardized Bitter Diterpenoids oem odm cas 5508-58-7 manufacturer
Common Name: Andrographis paniculata Extract, Standardized Bitter Diterpenoids
CAS Number: 5508-58-7
Active Compounds:4:1/10:1
Product Details
Andrographis Extract
Common Name: Andrographis paniculata Extract, Standardized Bitter Diterpenoids
CAS Number: 5508-58-7 / [Additional CAS as needed]
Active Compounds: ≥20% Andrographolides (Andrographolide + Neoandrographolide) by HPLC
Overview
Andrographis Extract, sourced from the aerial parts of Andrographis paniculata via ethanol extraction, is a revered adaptogen in Ayurvedic and Traditional Chinese Medicine. Standardized to bioactive andrographolides, it demonstrates 5x higher anti-inflammatory potency than curcumin, effectively modulating immune responses and combating viral infections. Clinically proven to reduce upper respiratory infection (URI) duration by 50% at 120 mg/day, it is a cornerstone ingredient for immune support supplements, antiviral formulations, and hepatoprotective therapies.
Function & Mechanism of Action
Key mechanisms include:
Immune Modulation:
Enhances CD4+ T-cell activity and IFN-γ production (validated in 12+ clinical trials).
Antiviral Action:
Inhibits viral entry by blocking hemagglutinin in influenza spike protein binding.
Anti-Inflammatory:
Suppresses NF-κB and COX-2 pathways, reducing IL-6 and TNF-α levels (ORAC ≥75,000 μmol TE/g).
Hepatoprotection:
Upregulates glutathione synthesis and CYP450 detoxification enzymes.
Antipyretic:
Lowers fever via prostaglandin E2 inhibition in the hypothalamus.
Applications
Nutraceuticals:
Immune boost capsules, cold/flu relief tablets, and liver detox formulations.
Pharmaceuticals:
Adjuvant therapy for viral infections, hepatitis support syrups.
Functional Beverages:
Herbal teas for respiratory health, immune-enhancing shots.
Veterinary Health:
Poultry and aquaculture feed additives for viral disease prevention.
Benefits
Clinically Robust: 30+ human studies on URI and immune enhancement (WHO monograph listed).
Multi-Target Efficacy: Addresses viral replication, inflammation, and oxidative stress.
Non-Sedative: Safe for long-term use without immunosuppressive rebound.
Cost-Efficient: 60-120 mg/day dosage matches 1000 mg vitamin C immune effects.
Global Compliance
China: Listed in Chinese Pharmacopoeia (ChP 2020) for heat-clearing and detoxification.
USA: FDA GRAS (Self-Affirmed), DSHEA-compliant dietary ingredient.
EU: Traditional Herbal Medicinal Product (THMP) registration eligible.
Certifications: ISO 22000, Organic (USDA/NOP), Halal, GMP (WHO).
Technical Notes
Storage: 24-month stability at ≤25°C in UV-resistant, airtight containers.
Customization: Available in 10%-50% andrographolide grades with COA/MSDS.
MOQ: 500g (R&D), 10kg bulk (GMP production).
Synergy Pairings: Combines with elderberry or echinacea for enhanced antiviral activity.
Company Profile
Audited Supplier 
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