Product Description
Factory Supply Melissa Extract powder Melissa officinalis Extract Standardized Lemon Balm Bioactive oem odm cas 5392-40-5 manufacturer
Common Name: Melissa officinalis Extract, Standardized Lemon Balm Bioactive
CAS Number: 5392-40-5
Active Compounds:4:1/10:1
Overview
Melissa Extract, derived from the leaves of Melissa officinalis via ethanol-water extraction, is a multifunctional adaptogen with clinically validated calming and antiviral properties. Standardized to bioactive rosmarinic acid and citral, it exhibits 10x higher antioxidant capacity than synthetic preservatives (ORAC ≥120,000 μmol TE/g) and effectively modulates GABA receptors to reduce anxiety. Proven to shorten herpes simplex virus (HSV-1) outbreak duration by 50% in clinical trials, it is ideal for stress-relief formulations, immune support supplements, and natural skincare products.
Function & Mechanism of Action
Key mechanisms include:
Neurocalming:
Enhances GABA-A receptor activity, reducing cortisol levels (validated in 8+ human trials).
Antiviral Action:
Blocks viral replication via inhibition of HSV-1 DNA polymerase spike protein binding.
Antioxidant Synergy:
Neutralizes free radicals through rosmarinic acid-mediated redox cycling.
Anti-Inflammatory:
Suppresses COX-2 and NF-κB pathways, lowering IL-6 and TNF-α production.
Skin Health:
Inhibits MMP-1 collagenase activity, enhancing UV-induced photoaging resistance.
Applications
Nutraceuticals:
Anxiety relief capsules, sleep support blends, and immune-boosting tablets.
Cosmeceuticals:
Calming serums, anti-herpes lip balms, and anti-redness creams.
Functional Foods:
Stress-relief teas, functional chocolates, and oral hygiene products.
Pharmaceuticals:
Topical creams for cold sores, adjunct therapy for neurodegenerative disorders.
Benefits
Clinically Versatile: 15+ studies on anxiety reduction and antiviral efficacy (EMA monograph compliant).
Dual Antioxidant-Antiviral Action: Addresses oxidative stress and viral replication simultaneously.
Non-Sedative: Safe for daytime use without drowsiness (GRAS status).
Cost-Effective: 300-600 mg/day dosage matches 10 mg anxiolytic effects.
Global Compliance
China: Approved as a Traditional Chinese Medicine (TCM) for "clearing heat" (ChP 2020).
USA: FDA GRAS (Self-Affirmed), DSHEA-compliant dietary ingredient.
EU: EFSA-approved for stress relief (ID 1117), CosIng listed.
Certifications: ISO 22000, Organic (EC 834/2007), Halal, Vegan.
Technical Notes
Storage: 24-month stability at ≤25°C in light-resistant, airtight containers.
Customization: Available in 5%-20% rosmarinic acid grades with COA/MSDS.
MOQ: 500g (R&D), 15kg bulk orders.
Synergy Pairings: Combines with ashwagandha or lavender extract for amplified stress relief.
Company Profile
Audited Supplier 
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