Product Description
Factory Supply Perilla Extract powder Perilla frutescens Extract, Shiso Extract oem odm cas 20283-92-5manufacturer
Perilla Extract
Common Name: Perilla frutescens Extract, Shiso Extract
CAS Number: 20283-92-5
Active Compounds: 4:1/10:1/flavones 5%
Overview
Perilla Extract, derived from the leaves of Perilla frutescens through ethanol-water extraction, is a bioactive-rich ingredient standardized to ≥10% rosmarinic acid. This polyphenolic compound is renowned for its potent anti-inflammatory, antioxidant, and anti-allergic properties. With 3x higher bioavailability than raw herb preparations, it is clinically validated to support immune modulation, respiratory health, and skin vitality, making it a premier choice for nutraceutical, cosmetic, and therapeutic formulations.
Function & Mechanism of Action
Key mechanisms include:
Anti-Inflammatory Action:
Inhibits COX-2 and NF-κB pathways to reduce pro-inflammatory cytokines (e.g., TNF-α, IL-6).
Antioxidant Protection:
Scavenges free radicals via ROS neutralization and enhances cellular glutathione synthesis.
Allergy Relief:
Blocks histamine release from mast cells and suppresses IgE-mediated allergic responses.
Skin Barrier Enhancement:
Upregulates ceramide synthesis and collagen production to improve hydration and elasticity.
Applications
Dietary Supplements:
Allergy relief formulas, immune boosters, and respiratory health blends.
Cosmeceuticals:
Anti-aging serums, acne treatments, and eczema/psoriasis creams.
Functional Foods:
Added to beverages, snacks, or fortified foods for antioxidant support.
Pharmaceuticals:
Adjuvant therapy for asthma, dermatitis, and chronic inflammatory conditions.
Benefits
Clinically Proven: 15+ human trials on allergy symptom reduction (e.g., rhinitis, asthma) and skin health improvement.
Multi-Target Efficacy: Addresses inflammation, oxidative stress, and immune dysregulation simultaneously.
Natural & Safe: Non-toxic (LD50 >4,000 mg/kg), non-GMO, and free from synthetic additives.
Synergistic Potential: Enhances effects of quercetin, vitamin C, and omega-3 in formulations.
Global Compliance
China: Approved as a Food Ingredient (GB 2760-202X).
USA: FDA GRAS (GRN 001128).
EU: EFSA-approved for food use (Regulation (EC) No 258/97).
Certifications: ISO 22000, HACCP, Halal/Kosher, Organic (USDA/EU).
Technical Notes
Storage: 24-month stability in airtight containers at ≤25°C, protected from humidity.
Dosage: 50-200 mg/day standardized to 10% rosmarinic acid (clinical effective range).
Customization: Available in 5%-20% rosmarinic acid concentrations, with COA, MSDS, and stability data.
MOQ: 500g (R&D), 15kg drum (commercial scale).
Company Profile
Audited Supplier 
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